The main roles in this series are for the GP and single mother Lydie van der Ploeg and her son Gert-Jan and daughter Nancy. She has a housekeeper called Mien Dobbelsteen, who is married to construction worker Koos Dobbelsteen. Lydie, who is very forgetful, gets a relationship with surgeon Hans Lansberg with whom she later married. Daughter Nancy moves abroad. The girlfriend of Gert-Jan, Pien, comes to live together with the family in place of Nancy.
After the birth of a son, Pien and Gert-jan divorce and Pien leaves. Gert-Jan gets a new girlfriend, Teuntje. Later, Gert-Jan, who also became a GP and the business partner of Lydie, left with Teuntje abroad. After that, the niece of Hans, Wiep, comes in and gets a relationship with the new business partner of Lydie, John Wijntak. They will live in the house next to Lydie. On the other side, Buys lives for a long time, but he leaves to Moscow. The sister of Mien Dobbelsteen, Annie, marries the friend of Koos, free-rider Jopie Schellenduin.
The role of Lydie van der Ploeg is played by Sjoukje Hooymaayer. Carry Tefsen has the role of Mien Dobbel- steen and John Leddy is played by Koos Dobbelsteen. Manfred de Graaf plays Hans Lansberg and Hans Cornelissen plays Gert-Jan van der Ploeg.
The series are directed by Nico Knapper, Chiem van Houweninge and Alexander Pola. It is one of the longest running sitcoms in the Netherlands!